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Study Reveals Rapid Weight Regain After Stopping GLP-1 Medications

KVIA•Thursday, January 8, 2026 at 5:33 PM•CNN Newsource

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A recent review from the University of Oxford indicates that individuals who discontinue GLP-1 weight loss medications, such as Ozempic and Wegovy, are likely to regain weight within two years. The study analyzed 37 research papers involving over 9,300 adults, finding that weight regain occurs at a rate of approximately 0.3 kg (0.7 pounds) per month faster than those who lose weight through lifestyle changes. Experts emphasize that this underscores the chronic nature of obesity and the need for comprehensive weight management strategies that include behavioral support. As more than 15 million Americans utilize these medications, the findings highlight the importance of ongoing nutritional guidance and exercise to maintain weight loss and prevent muscle loss, particularly in older adults.

Key Details: • Weight regain after stopping GLP-1 drugs is about 0.3 kg (0.7 pounds) per month faster than lifestyle changes. • Over 15 million Americans are currently using GLP-1 medications for weight loss. • Ongoing nutritional and behavioral support is crucial for effective long-term weight management. • Engaging in strength training is recommended to prevent muscle loss during weight loss.

health weight-loss obesity medications nutrition

People & Organizations

Sam WestAdam CollinsMarie SpreckleyUniversity of OxfordUniversity of SurreyUniversity of Cambridge

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