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Study Reveals Heart Health Benefits of GLP-1 Medications Disappear Quickly After Stopping

KVIA•Wednesday, March 18, 2026 at 4:00 PM•CNN Newsource

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Recent research highlights the rapid loss of heart health benefits from GLP-1 medications, commonly used for diabetes management. The study found that individuals who discontinue these medications see a significant increase in heart risks within six months, with risks rising by 22% by the second year off the drugs. This underscores the importance of continuous treatment for maintaining cardiovascular health. The findings, based on over 333,000 patients, emphasize that while GLP-1s can lower the risk of heart attacks and strokes, stopping the medication can quickly reverse these benefits. Patients are encouraged to discuss ongoing treatment options with their healthcare providers to ensure sustained heart health.

Key Details: • Heart risks increase by 4% after six months off GLP-1 medications. • After one year off, the risk rises by 14%, and by 22% after two years. • The study involved over 333,000 patients treated through the Veterans Health Administration. • Patients are advised to maintain medication for continued heart health benefits.

health research medication cardiovascular diabetes

People & Organizations

Dr. Ziyad Al-AlyDr. Melanie JayVeterans Health Administration

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